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Basal cell fate and cell cycle time is random.
Since the embryo proper has few cells, especially when compared to other flowering plants, this suggests that the rate of cell division is slow and/or the cells have a long cell cycle time.
In-vivo tritium labeling studies by Weinstein from the 1980's predicted a cell cycle time of 311 hr in normal epidermis, 8 fold longer than the 36 hr cell cycle period in psoriatic epidermis[20].
Responding CD8+ T cells with fast initial cell cycle time differed in transcriptome profile from the responding cells with slow initial cell cycle time.
Therefore the responding T cells had divided with an apparent cell cycle time of ∼2 hrs.
Let the cell cycle time of the LTP cells be denoted by cl.
The difference in the initial cell cycle time of CD8+ T cells responding to i.n.n
The T cell cycle time varies with duration of the G1 phase of the cell cycle.
The cell cycle time of responding T cells in vivo was not fixed (uniform).
Also, we observed the same rapid cell cycle time, when a10-fold lower inocula of CL-4 T cells were used for transfer (Figure S1C).
The initial cell cycle time of responding CD8+ T cells is not fixed but is controlled by the antigenic stimulus provided by the APC in vivo.
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