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Understanding of the cell cycle control logic in Caulobacter has progressed to the point where we now have an integrated view of the operation of an entire bacterial cell cycle system functioning as a state machine.
We set out to gain insight into this matter using the in vitro cell cycle system derived from Xenopus eggs.
Using the in vitro cell cycle system derived form Xenopus eggs, here we show, however, that inhibitory phosphorylation of cdk1 contributes to control MPF activity during M-phase exit.
Our model is validated with the well-known cell cycle system.
S CC) denotes the cell cycle system, and M (X) the inferred models and their underlying rate law formulations.
The network structure of this 11-gene yeast cell cycle system consists of 15 activating and 14 repressing influences [ 24].
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Note that three of the reactions of the p53 system, one of the NF-κB system and the coupling between the NF-κB and the cell cycle systems employ kinetics that are not mass action and are converted to reactions with parameters that respect their specific kinetic functions.
We showed that it can determine coherent pathways and regulatory mechanisms that connect genetic perturbations to target genes (in yeast and human data), as well as coherent modules, regulators and pathways in the yeast cell-cycle system.
In order to assess this, we have performed various reverse-engineering experiments on synthetic data based on three different 5-gene GRN systems, as well as on data obtained from an 11-gene yeast cell-cycle system [ 11].
Moreover, in contrast to the cell cycle arrest system, the apoptosis induction system is responsible for safeguarding the system that suppresses malignant transformations.
The p53 ambidextrously controlled the implementation of both the cell cycle arrest system and apoptosis induction system with employing the diversity of own dynamic behaviors.
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