Sentence examples for cell cycle steps from inspiring English sources

The establishment and maintenance of chromosome condensation are essential cell cycle steps that facilitate accurate chromosome segregation and therefore ensure the integrity of eukaryotic genomes.

CYCLIN E, that regulates cell cycle steps critical for growth control, had been demonstrated to be overexpressed in many malignant tumours (for a review see Möröy et al. [12]), and in particular it could be useful to assess malignancy of blasts in adult B- and T-ALL [13].

Among the few proteins known to form interaction complexes with the SH3 domain of RasGAP, Aurora kinases and Survivin are particularly compelling because of their involvement in the regulation of multiple cell cycle steps, in cell survival and in tumorigenesis [16], [17].

We postulated that the increase/decrease in growth rate is due to a change in the rate of progression through specific cell cycle steps.

However, the tomato fruit model system proposed by Gillaspy has shown its importance to decipher early developmental determinants, cell cycle steps and organ number determination [ 14- 16].

However, treatment with drugs that interfere with several cell cycle steps result in the ectopic accumulation of nuclei in the neuroepithelia of developing mouse and zebrafish (Ueno et al. 2006; Kosodo et al. 2011; Leung et al. 2011).

Both the in vitro and in silico cell cycle profiles of the partial slt2 deletants are comparable to the WT – suggesting, interestingly, that the increased growth rate is not due to the cell speeding through one particular cell cycle step, as we observed in other mutants, but rather that all stages (or, at least, both G1 and G2; Figure  3b) proceed at an accelerated rate.

The tsBN67-cell proliferation assay used in the aforementioned experiments assays the role of the HCF-1 Basic region in supporting cell proliferation but does not define the cell-cycle step(s) involved.

RhoA signalling regulates G1 S phase transition, and one of the crucial target genes of Rho signalling during this cell-cycle step is the cyclin D1 gene (Coleman et al, 2004; Ridley, 2004).

In a more recent study, Plk1 was implicated in a G2 DNA damage response checkpoint required for the stabilization of Claspin and dependent on the ubiquitin ligase APC/Ccdh and the phosphatase Cdc14B, a protein previously implicated in a later cell cycle control step during mitotic exit [35].

The Rb pathway controls the cell cycle entry step into the DNA replication phase [ 46].