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Robustness was interpreted as involving stability of G1 steady state and sequence of gene expression from cell cycle START to stationary G1.
Our data showed that HOC is not strictly separated from DNA replication; rather, cell cycle Start is coupled with the initiation of HOC and catabolism of storage carbohydrates.
Burnetti, AJ; Aydin, M; Buchler, NE, Cell cycle Start is coupled to entry into the yeast metabolic cycle across diverse strains and growth rates., Molecular Biology of the Cell, vol. 27 no. 1 (January, 2016), pp. 64-74 [doi]sitory], [doi].
Burnetti, AJ; Aydin, M; Buchler, NE, Cell cycle Start is coupled to entry into the yeast metabolic cycle across diverse strains and growth rates., Molecular Biology of the Cell, vol. 27 no. 1 (January, 2016), pp. 64-74 [doi]sitory], [abs] [abs].
When haploid cells of mating type a and α meet, they extend a projection toward the other ("shmoo"), stop their cell cycle, start transcription of mating genes, and finally fuse to form a diploid cell.
CCND3 is expressed in nearly all proliferating cells and could promote the cell cycle start (44).
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All together these data suggest that the deregulation of the cell cycle starts at late developmental embryonic stages and has cumulative effects resulting in major defects in brain development accompanied by perinatal death in triple mutant mice.
In our experiments MCF-7 accumulated in G1/S phase of cell cycle starting as early as 24 hours post-treatment.
Meeks and Elhai [1] proposed a two-stage model of pattern formation in which four contiguous (synchronous) cells at similar favorable stages in their cell cycles start to differentiate after nitrogen step-down and then undergo competitive resolution to select a single heterocyst.
"But when you have a cancerous event, like a tumor, those cells have adopted a selfish behavior again". Without the RB gene to regulate the cell cycle, cells start to divide without concern for the other cells they share space with — a process that can often turn deadly.
In the CNS, the expression of Sox1-3 is confined to self-renewing precursor cells, but is generally downregulated as cells exit the cell cycle and start to differentiate into neurons or glia [9], [19].
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