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Traditional experiments with bacteria have shown that when the external nutrient concentration is changed cell size and growth rate follow transient trajectories, that require different periods of time to reach the new cell cycle regime [ 23, 24].
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Here, we show that the expression of most of the organelle genes is highly coordinated with the cell cycle phases as well as with light regimes in clustering analyses.
Theoretical studies have shown that a deterministic biochemical oscillator can become chaotic when operating over a sufficiently large volume and have suggested that the Xenopus laevis cell cycle oscillator operates close to such a chaotic regime.
Also, in a short duty cycle regime (i.e. if a cell exerts synaptic action over a short part of the cycle), it is applicable to spiking neurons, in which an intrinsic regenerative mechanism is fast compared to recovery variable time scale [16].
As deregulation of the cell cycle machinery and ER signaling both contribute to hormonal therapy resistance, a roscovitine treatment regime that suppresses both these pathways could serve as a double-edged sword to interfere with the hormonal therapy-resistant mechanisms.
The noise reduction is in the physiologically relevant low-frequency regime, and in Fig. 4 we have indicated the typical values for a cell cycle and mRNA lifetime.
Cell Cycle.
We use a model of the embryonic cell cycle to illustrate the approaches that can be used to characterize the domain of parameter space corresponding to limit cycle oscillations, a regime that coordinates periodic entry into and exit from mitosis.
Synthesis during the cell cycle.
Cell cycle of somatic donor cells.
Rocaglamide treatment leads to cell cycle arrest.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com