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In contrast, tumor cells that undergo aberrant cell cycle re-entry divide and can survive.
The second approach, inducing myocyte cell cycle re-entry, is accompanied by both efficacy and safety concerns.
Apoptotic signaling is initiated and the fiber undergo cellularization, which involves cell cycle re-entry and dedifferentiation.
However, increasing evidence over the last decade supports the notion that neuronal cell cycle re-entry results in post-mitotic death.
We also discuss the pharmacological approaches that interfere with the mitogenic pathways and prevent mature neurons from attempting cell cycle re-entry, protecting them from cell death.
Barx2 expression in C2C12 myotubes increased the expression of cyclin D1, which may promote cell cycle re-entry.
Conversely, MVs derived from stem cells may induce de-differentiation of cells survived to injury with a cell cycle re-entry that may allow tissue regeneration [7].
Cell cycle re-entry of normal cells was unaffected by release in 0 mM glutamine, regardless of the presence of nucleotides (Figure 7, panels A, C and E).
Sage et al. reported that acute loss of Rb in mouse embryonic fibroblasts induced cell cycle re-entry and cell proliferation; whereas germline loss of Rb did not.
Interestingly, RNAi inhibition of Rb family members in C2C12 myotubes suggests that knock-down of p107 plus p130 does not cause cell cycle re-entry [59].
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Here we discuss only our most marked experimental data that support the conclusion that cell-cycle re-entry is prominent in the AAV-Tau model.
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