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In protonemata, transcript accumulation was increased in genes involved in cell wall synthesis, photosynthetic processes, carbohydrate biosynthesis, cellular morphogenesis, cell size regulation, cell generation, cell cycle processes, and cytokinesis (Supplementary Figure S1; Supplementary Table S1).
The hypothesis that distinct chromatin domains expand and are remodelled differently when they undergo transcription, replication or cell cycle processes is well accepted.
Functional analysis of the genes exhibiting the most abundant alternative splicing events, namely skipped exon and retained intron events, revealed the enrichment of mRNA processing, apoptotic signaling pathways, protein polymerization, cell development and differentiation for the former and the enrichment of cell cycle processes, stress and splicing regulation for the later type of events.
Although histones and their modifications are highly conserved, their distribution in chromosomes, observed by immunolocalization, showed a variation over the differentiation and cell cycle processes, as well as within and between groups of eukaryotes (Hans and Dimitrov [2001]).
Not surprisingly, the majority of these terms related to cell cycle processes, with mitotic cell cycle, GO 0000278 being the most significant, p = 2.62 × 10−42 (Additional file 5: Table S3).
In addition to the increased collaboration, the intellectual critical mass existing within the IMCB also helped the learning process through stimulating discussions with seasoned experts in exciting topics such as signal transduction and cell cycle processes.
Similar(5)
As a result, time-series measurements from synchronized cell populations do not reflect the underlying dynamics of cell-cycle processes.
Here, we present a branching process deconvolution algorithm that learns a more accurate view of dynamic cell-cycle processes, free from the convolution effects associated with imperfect cell synchronization.
A recent proposal suggests CDK acts as a master regulator of cell-cycle processes that have the potential for autonomous oscillatory behavior.Here we find that mitotic CDK is not sufficient for fully inhibiting transcript oscillations in arrested cells.
Besides, baker's yeast is a well-studied model organism, and the dataset quantifies the well-understood cell-cycle processes, which makes it easy to interpret the results.
The progression through the cell cycle can be halted at several checkpoints where completion of cell-cycle processes is monitored.
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