TAG tumors had major ontologies representing genes involved in cell cycle, cell organization, cytoskeleton organization and biogenesis, and cell organization and biogenesis.
For GCs overexpressed genes these functions were mostly related to metabolic processes, transport, proteolysis, regulation of transcription, immune response and cell adhesion, whilst for the mature oocyte they were mostly related to cell cycle, chromosome organization, phosphorylation and dephosphorylation of proteins, multicellular organism development and DNA metabolic process.
Up-regulation of genes involved in cell cycle and organization during compatible interaction (Ref 9) also promotes establishment of nutritive tissue at feeding sites (Ref 10).
The small GTPase Rac1 is involved in the regulation of critical cellular functions, such as transcription control, cell cycle, and organization of actin cytoskeleton.
Gene ontology functional analysis of the differentially expressed genes indicates that surface modification of MPLA biomaterial has an extensive influence on cells by regulating expression of genes related to cell proliferation, cell cycle, cytoskeleton organization, ossification, bone remodeling, metabolism, and eventually induces osteoblast proliferation and differentiation.
On the other hand, genes involved in cell cycle and organization of cellular organelles, lipid metabolism and sterol synthesis were down-regulated in strain R265.
Genes controlling the cryptococcal cell cycle and organization of cellular organelles may also affect virulence as seen in several fungal pathogen including U. maydis [50], C. neoformans [51] and S. cerevisiae [52].
Female-enriched genes were represented by several GO classes such as nucleotide binding, nitrogen metabolism, cell cycle, cytoskeleton organization and organelles.
Significantly upregulated targets during the luteal phase were enriched for functions relating to cell cycle, cellular organization and repair, and DNA replication, recombination, and repair.
