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This was explained by the difference in cell cycle progression observed using flow cytometry, as it was found that only 20%HHx-containing polymer could maintain the normal cell cycle evolution as TCPs did after 3 d incubation.
Cell cycle evolution in the fungal ancestor then proceeded through a hybrid network containing both SBF and its ancestral animal counterpart E2F, which is still maintained in many basal fungi.
We also studied the effect of Rac3 knockdown in breast epithelial cells and showed in these cells that Rac3 inhibition had not effect on the cell proliferation, morphology, actin organization and cell cycle evolution.
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The keywords cancer, stem cell, cell cycle and evolution approximated the typical pattern of all scientific output.
The topic of stem cells (Fig. 3A) is slightly smaller, yet there is still a substantial output, as is also the case for cell cycle and evolution (Dataset S1).
Explores modeling basic biological processes (e.g., transcription, splicing, localization and transport, translation, replication, cell cycle, protein complexes, evolution) from a systems biology perspective.
We believe that the emergence of the CDK4/6-cyclin D complex may have contributed to the formation of eumetazoan-specific G1 phase regulation, and may represent a key step in the development of cell cycle regulation during eumetazoan evolution.
Hanschen, E. R. et al. The Gonium pectorale genome demonstrates co-option of cell cycle regulation during the evolution of multicellularity.
The phenotypes, including chromosome hypercondensation, aberrant segregation, and polyploidy, are reminiscent of the defects observed in Ubc9-deficient mouse embryos and Drosophila embryos mutant for pias, a possible SUMO ligase [13], [72], indicating conservation of SUMO cell cycle functions in metazoan evolution.
These findings indicate that cell cycle constraints drive the evolution of gene-architecture and shape the transcriptome of a given cell type.
Comparative genomic analyses can provide valuable insights into the organization of cell cycle machinery and the evolution of these protein complexes.
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