Other gene categories represented included those involved in metabolism, cell cycle, development, proteolysis and apoptosis.
Many of the hub genes were related to the cell cycle, development, and signaling pathways important for ESC development.
The embryos of the African clawed frog X. laevis have been of great use to researchers studying the cell cycle, development, and the connections between the two.
Our data provide a large resource for studies on the interaction between plant checkpoints of the cell cycle, development, hormone response, and DNA repair functions, because IR-induced transcriptional changes partially overlap with the response to environmental stress.
Since the Polycomb group gene Bmi1 is involved in the regulation of development and tumorigenesis, the effect of Bmi1 downregulation in GBM cells was screened by analysis of proteins involved in key cellular pathways of the cell cycle, development, metabolism, apoptosis and growth, including Erk, Akt, GSK3β, p16 and p14, Bcl-2, c-Myc, Nestin and Sox2.
Recently, numerous capped cellular mRNAs were discovered also to contain IRESs in their 5'-UTRs and shown to utilize IRES mediated translation initiation when normal cap dependent translation is severely compromised during conditions of cell stress, cell cycle, development and diseases [3].
Our search strategy yielded several genes that were consistently enriched in normal hematopoietic GE datasets and were found to be involved in cell cycle, growth, development and hematopoiesis by functional pathway analysis.
Pathway analysis of potential driver genes in Table 1 showed top molecular functions of these genes to be involved with cell cycle, cellular development, growth and proliferation.
Two relevant examples of coordination between the cell cycle and development are found in oocyte meiotic maturation during oogenesis and in the specialized early embryonic mitoses.
Red rectangle represents differentially expressed genes involved in cell division, cell cycle and development related pathways.
The relationships between metabolism, the cell cycle, and development are unclear and demand further exploration.
