Sentence examples for cell cycle deregulation from inspiring English sources

The cell cycle deregulation leads to neurogeneration.

CDKs (CDK1, CDK2, and CDK5) have been associated with tau hyperphosphorylation, amyloid precursor protein processing, and apoptosis due to the cell cycle deregulation in AD [31].

As described in the previous sections, cancer cells exhibit critical metabolic transformations induced by mutations that result in cell cycle deregulation associated with enhanced cellular stress.

The oncogenesis of HPV+ SCCHN goes beyond cell cycle deregulation, and relies on the immune escape through (E5, E6, and E7) downregulating antigen processing, interferon response, as well as STAT-1 signaling.

It is known that cell cycle deregulation is a general feature of malignancy.

Genetic evidence indicates that stat92E contributes to cell cycle deregulation and excess cell size phenotypes that are observed among ept mutant cells.

As the hallmark of cancer revolves around cell-cycle deregulation, it is not surprising that antimitotic therapies are effective against the abnormal proliferation of transformed cells.

This finding can be explained not only because of the cell-cycle deregulation caused by the loss of TP53 but also the usual requirement of chemotherapy, both independent predictors of a reduced OS and PFS (Table 1) [ 26, 57].

Part of the complexity of understanding cell-cycle deregulation in cancer has been the observation that specific abnormalities, such as cyclin gene amplification, have been found in only a fraction of tumors of a particular type.

It has been proposed that the loss of class I HDAC function could induce the hyperacetylation and activation of genes regulated by RB protein, thus leading to cell-cycle deregulation (Ropero and Esteller 2007).

Centrosome aberrations and cell-cycle deregulations have important implications for the development of endometrial carcinoma.