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The use of retinoid therapy in cancer is promoted by the ability of retinoids to induce differentiation, cell cycle cycle arrest and apoptosis [ 29, 30].
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Determining the variability of gap gene expression during early cell cycles (cycles 10 13) would be highly informative in addressing whether gap gene expression is initially variable in response to the Bcd gradient.
Transcription factors can have important roles in cancer, if they influence the activity of genes involved in the cell cycle (or cell division cycle).
As VS-mediated chemotherapy is primarily targeted towards the cell cycle, cell-cycle analysis was performed with GNP, VS, and GNP-VS.
Owing to its fundamental roles in cell cycle phases, the cell division cycle 25B (CDC25B) was broadly considered as potent clinical drug target for cancers.
Cell cycle-specific, cell cycle-non specific, cell cycle phase-specific and cell cycle phase-non specific drugs can be simulated, as detailed in [23].
Because cell proliferation is closely linked to progression of the cell cycle, cell cycle analysis was performed by flow cytometry.
Treatment with zeocin from the beginning of the cell cycle blocked cell cycle progression in G2 phase with duplicated DNA.
This analysis revealed five significant categories pertaining to cell cycle, including cell cycle (p = 0.0005), cell cycle arrest (p = 0.0007), negative regulation of cell cycle (p = 0.001), mitosis (p = 0.005) and regulation of cell cycle (p = 0.039) (Table 2).
For example, terms associated with cell cycle ('cell cycle'mitosis'is', 'M phase', and 'spindle') were highly enriched within cluster 3 and were not associated with any other cluster.
We postulate that this role is to inhibit cell cycle progression and promote cell cycle exit.
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