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Mechanisms involved in S phase arrest have been pinpointed to downregulation of signalling and altered expression of cell cycle controller proteins, including E2F1, a transcription factor with ability to play a part in apoptosis.
One has found an important cell cycle controller.
One has discovered an important cell cycle controller.
p21cip is a cell cycle controller which is critical for determining the outcome of p53 activation.
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Membranes were blocked for 2 hours in 5% BSA and incubated overnight at 4°C with antibodies against γ-H2AX, ATM, ATR, Chk1, cell-cycle controller-2 (Cdc2), E-cadherin, vimentin, caspase-3, and caveolin-1 (Cav-1).
The miR-290-295 codeser codes a family of miRNAs that was identified as cell-cycle controllers via targeting of the cell-cycle regulator genes, Wee1 and Fbxl5 (Lichner et al, 2011).
Tumor suppressor genes can be classified by their various functions, such as those which operate as transcription factors, DNA damage sensors, cell cycle checkpoint controllers, etc. [5].
The Nek7 gene has recently been identified in the testes [25] where it is likely to be a prime controller of cell cycle progression and mitotic spindle assembly [26].
Cell cycle_1 collects most of the canonical controllers of cell cycle progression and is linked to several DNA processing pathways, as discussed in the Results section.
Since first discovered more than a decade ago [ 128,21] the Aurora kinase family has emerged as a major controller of the cell cycle and mitosis.
PPARγ is also a general transcriptional controller of processes, such as cell cycle carcinogenesis, inflammation, atherosclerosis and immunomodulation.
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