In this model, blood vessels are destroyed after a fixed number of time steps tf rather than being occluded by cell crowding.
Such protective effect may enhance tumor cell crowding in niche, and the contact may also serve to distribute vital signals from unreachable niche components like osteoclasts, vascular vessels and stromal cells, thereby overcoming the limited access to these regulators.
When the team left dishes of cells crowded for 2 weeks, they found that one highly mutating gene, called HPRT, had mutated 7900 times faster than in cells grown at low density, even though the crowded cells weren't dividing.
Little pink balloons swelled into view ahead of him, like engorged blood cells, crowding and bumping.
The more cells crowding into the edge of the tumor, the better.
Eventually the proliferating malignant cells crowd out good cells and the body can no longer fight infection.
This reciprocity is easily comprehensible when there is a direct contact between Nestin+ cells and endothelial cells, as it happens in capillaries or small vessels; it is more difficult when Nestin+ cells crowd around vessels with a thicker wall.
It remains possible that a mechanism of active displacement is involved in CySC dominance (i.e., the colonizing stem cells crowd out the wild-type ones), and live-imaging of competing clones might distinguish between passive replacement and active displacement.
Mean image intensity was selected as a feature that may be useful to separate normal lymphoid tissue from metastatic tissue because malignant cells crowd together, are enlarged, and are hyperchromatic with H&E stain.
In particular, using real FCS data, we describe how the effects of cell crowding and binding to affinity sites manifest themselves in the behavior of G t).
