Sentence examples for cell conditional from inspiring English sources
A very novel and interesting part of the work was the in utero electroporation to obtain single cell conditional deletion of Aph1BC, and thereby investigate the effects of abrogation under physiological conditions in a wild-type background.
Thus, T cell conditional Chop null mice (Ddit3T cell-KO) were generated by crossing Ddit3flox/flox and CD4-Cre mice.
In this study, we show that T cell conditional ablation of MEKK3, a Ser/Thr kinase in the MAPK cascade, causes a significant reduction in peripheral T cell numbers in the conditional knockout mice, but does not perturb thymic T cell development and maturation.
The finding that ELG1 deletion suppresses ctf7 mutant cell temperature sensitivity suggests that ELG1 over-expression might in turn exacerbate ctf7 mutant cell conditional phenotypes.
Second, we took advantage of prior studies that deletion of ELG1 suppresses both ctf7 mutant cell conditional growth and sister chromatid defects, identifying Elg1-RFC as an anti-establishment factor that likely directly opposes Ctf7 function [27], [28].
Given that rad61 bypasses completely ctf7 null cell lethality under these conditions, the finding that rad61 deletion is not sufficient to suppress ctf7 ctf18 mutant cell conditional lethality is consistent with the model that Ctf18-RFC exhibits establishment activities beyond those associated with Ctf7.
In normal adult beta-cells, conditional NFAT activation promotes the expression of cell-cycle regulators and increases beta-cell proliferation and mass, resulting in hyperinsulinaemia.
Here we show that in epithelial cells conditional activation of the ERK pathway causes phenotypic conversion of epithelial cells to autonomously migrating cells.
Using T-cell conditional knockout mice deficient for Abl family kinases, Abl (Abl1) and Abl-related gene (Arg) (Abl2), it was recently shown that loss of Abl kinases results in defective T-cell development and a partial block in the transition to the CD4CD8 stage.
T-cell conditional FoxM1 knockout mice were generated by crossing FoxM1flox/flox mice to Lck-Cre or CD4-Cre transgenic mice, which express Cre recombinase at different DN stages.
CD4 cells from wild-type (Stat3+/+) mice and T-cell conditional Stat3 knockout (Stat3−/−) mice (Takeda et al., 1998) were activated in the absence or presence of IL-6, and MMP was examined 48 hr later.
