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Analyses of several GEM mammary cancer models suggested that tumors from certain models may be enriched for cells with stem cell characteristics compared with other models.
Seemingly, the postulated critical MTX concentration for these 4 cell pools transfected with the pAIDp or pAI772Dp vectors was not crossed at 300 nM MTX, resulting in similar cell characteristics compared to the corresponding 50 nM MTX cell pools.
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Furthermore, its unique cell cycle characteristics compared to other yeasts (e.g., cell division through medial fission instead of budding) make it an ideal model in the studying mammalian cell cycle control.
However, primary DCs constitute a heterogeneous and minor population of cells not suited for screening and the choice would be a human DC-like cell line, with characteristics compared to primary DCs.
Tumours and tumour cells exhibit different characteristics compared to normal tissue and cells; this is reflected in altered physiology, tissue composition and expression of intra- and extracellular molecules [ 23, 24, 26– 28].
The parental ET cells display mesenchymal characteristics compared with the more-epithelial LA derivative, providing a unique opportunity to investigate the epithelial –mesenchymal axis in isogenic breast cancer cell lines [ 6, 31, 32].
To evaluate our material for stem cell characteristics, we compared the gene expression of the stem-like stage with findings reported or suggested by others.
Nuclear β-catenin has been shown to impose an undifferentiated progenitor phenotype on colorectal cancer cells (van de Wetering et al, 2002); therefore, the differentiation and expression of stem cell characteristics were compared between cells growing on plastic and type I collagen.
It is now accepted that the metabolism of cancer cells has extremely unique characteristics compared to the one of healthy nonproliferating cells [ 4].
In this report, we demonstrate that mesenchymal liver cancer cells (post-EMT) possess several TISC characteristics compared to epithelial cells.
Biofilm cells possess distinct phenotypic characteristics compared to their planktonic counterparts [7].
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