As published before6,8,9,15,28, we found that decreased β-cell cell function with oleate was not accompanied by fasting hyperglycemia, presumably indicating that initial reduction in β-cell cell function can only be detected by using β-cell challenge tests.
However, we have previously linked decreased β-cell cell function in our oleate infusion model with increased ROS and inflammation in islets6,7,8,9,28, which is suggestive of lipotoxicity.
Turchinovich, A., Samatov, T. R., Tonevitsky, A. G. & Burwinkel, B. Circulating miRNAs: cell-cell communication function?
The anemia associated with chronic disorders is characterized by abnormally low levels of iron in the plasma and excessive quantities in the reticuloendothelial cells (cells whose function is ingestion and destruction of other cells and of foreign particles) of the bone marrow.
Bves is a highly conserved transmembrane protein with cell-cell adhesion function that is expressed in a variety of epithelia and muscle from flies to humans.
Spatial organization in the nucleus of a cell governs cell function.
Mechanotransduction – the role of mechanical stress, cell shape, and cell architecture on cell function.
How HCV-infected PHT cells impaired NK cell function remains unknown.
Murine dendritic cell antigen-presenting cell function is not altered by burn injury.
Comparison of total cell number with viability and cell function are proportional (Fig. 2).
