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CS develops after decompression of limb muscles (reperfusion) following prolonged compression (ischemia) of a large portion of skeletal muscle, resulting in rhabdomyolysis (muscle cell breakdown).
Analysis of the cellular mechanisms leading to cell breakdown on physical stress may point the way to mutation-independent therapeutic approaches to these incurable genetic disorders.
We therefore subjected EBS cell lines, immortalized from patients with EBS, to an oscillating mechanical stress in assays designed to mimic the physical trauma that leads to cell breakdown in vivo.
One medical source close to the team treating Chavez in Venezuela said he had been suffering a condition called tumor lysis, or cell breakdown, and agreed there was no metastasis.
This process could lead to age-related cell breakdown, tissue deterioration, and death, although the correlation between telomere length and aging isn't perfect, and there's still plenty to learn.
Coggins suggested that low doses may cause cellular abnormalities, such as cell breakdown, delay of cell division and mitochondrial disturbances.
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appears later in life as well, because it takes a long time for the initial trauma to give rise to nerve-cell breakdown and death.
Another pathomechanism may be impaired myocyte metabolism or membrane dysfunction, resulting in muscle-cell breakdown or membrane leakage [ 15].
Interestingly, and in contrast to HCT116 wt cells, breakdown of ΔΨm followed DNA fragmentation upon TRAIL-treatment in HCT116 Bax−/Bak− cells, indicating that MMP occurs late and coincides with cellular demise instead of playing an early, regulatory role.
Major symptoms were alterations of the secondary lamellae epithelium (from extensive oedema to desquamation), hyperplasia of chloride cells, and breakdown of the pillar cell system.
A mechanical failure of a single component is sufficient to cause a solid oxide fuel cell (SOFC) breakdown.
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