Sentence examples for cell based screen from inspiring English sources

A novel high throughput-enabled human cell based screen, Anthem's Genotoxicity screen, was developed to achieve higher specificity for predicting in vivo genotoxins by an in vitro method.

Using a cell based screen, Tenovin 1 was identified to inhibit sirtuins activity [ 72].

We report the discovery of benzothiazoles, a novel anti-mycobacterial series, identified from a whole cell based screening campaign.

We have employed a live cell based screening platform to identify potential compounds that can induce programmed cell death in Bax deficiency.

The usefulness of 162 library compounds was evaluated by the cell based screening at melanocortin 4 receptor in CHO-k1 cells, to find hit compounds showing agonistic effect at the receptor.

The replacement of fetal bovine serum (FBS) with normal human serum (NHS) was found to be a crucial factor in the performance of the human cell based screening assay that enabled the calculation of mAb efficacy and potency.

We thank Connie Schmaljohn (USAMRIID) for monoclonal antibodies to RVFV, John Hogenesch (UPenn) for calcium-dependent transcriptional reporters and the Cell Based Screening Core (UPenn) for the LOPAC library, and use of the facility.

In the second step cell based screening, to our surprise, only one of the 14 selected TAs exhibited highly doxycycline-dependent binding to endothelial cells expressing E-selectin, despite the initial screening using human recombinant E-selectin proteisolatedted from the mammalian system.

In the 1960s, cell based screening of natural products by the National Cancer Institute identified taxol as a potent mitotic inhibitor [ 32].

In this study, we sought to systematically characterize the role of miRNAs in NF-κB signaling using high-throughput cell based screening.

Usage of our method as an additional analysis component of RNAi cell based screens should enable researchers to counter-screen for downregulation of sensitive transcripts and reduce the false positive siRNAs during the validation process.