Our previous work has shown that vascularization is an early event in cell based bone repair approaches [ 7].
These attributes of MSCs make them lucrative candidates for a cell based regenerative and repair therapy.
Usage of MSCs as cell based therapeutics for repair is strengthened by the fact that MSCs appear to escape immune surveillance [5].
Clinically relevant cell based therapies for tendon repair and regeneration could be created using tools that harness biophysical beacons (surface topography, mechanical loading), biochemical cues (oxygen tension), and biological signals (growth factors).
The induction or exacerbation of arrhythmias is a major concern in stem cell based therapies for cardiac repair, and the effect of regenerative treatments on cardiac electrogenesis is still under debate [5] [15], [46] [47].
The current cell based treatment methods for cartilage repair are based on the migration of bone marrow derived stem cells to the site of injury and include arthroscopic abrasion, subchondral drilling, and microfracture [ 2].
Skeletal muscle regeneration is an efficient stem cell-based repair system that ensures healthy musculature.
This review article focuses on the multitude of cell-based repair techniques for cartilage repair across several species, with special attention paid to the horse.
This chapter introduces the structure and function of articular cartilage, provides a brief overview of the cartilage injury and degeneration, and lists the challenges of cell-based repair.
Our cell-based repair program is exploring the potential of transplanted cells, including adult derived myelin forming cells, adult stem cells, and induced pluripotent stem cells to restore signal conduction in demyelinated axons, facilitate axon regeneration, and/or reduce neuronal loss.
Here we review the status of clinical and preclinical studies for stem cell-based repair, covering key eye tissues from front to back, from cornea to retina, and including bioengineering approaches that advance cell product manufacturing.
