Sentence examples for cell based activity from inspiring English sources

To investigate the role of P911 in receptor activation, we performed cell based activity assays with IGF1R-fl bearing either a single P911L substitution or with additional substitutions to residues surrounding P911.

Investigation of a series of 4,6-disubstituted-4H-benzo[1,4]oxazin-3-ones has led to the identification of single-digit nanomolar inhibitors of PI3Kγ, several of which had good cell based activity and were shown to be active in vivo in an aspectic peritonitis model of inflammatory cell migration.

Two different methods containing cell free chemical assay (1-diphenyl-2-picrylhydrazyl method) and cell based antioxidant activity test were used to evaluate the antioxidant capacities.

The results of cell based pERK activity and cellular selectivity suggested that those compounds could selectively inhibit proliferation of mutant BRAF-dependent melanoma cell line through inhibition of oncogenic BRAF.

We then characterize the identified small molecules using a cell based assay activity and highlight the selective binding of NSC260594 to the tetraloop of SL3 by H NMR spectroscopy.

If this hypothesis is tenable, we should not observe any relevant temporal structure arising from such cell ensembles, being all the relevant (and well known) cell based rhythmic activities averaged out, at the colony level, by the substantial independence of cells.

A novel and efficient approach for the preparation of enriched herbal formulations was described and their potential applications including wound healing and antioxidant activity (cell based and cell free) were investigated via in vitro cell culture studies.

In particular, rapid evaluation and optimization of the novel spiro 1,3,4-thiadiazolines resulted in a series of potent KSP inhibitors demonstrating mechanism based activities in cells, including induction of the mitotic marker phospho-histone H3 and induction of monaster spindle formation.

To demonstrate that these SIRT1 activators can directly increase mitochondrial content in a cell based model, we measured CS activity in C2C12 myotubes treated with vehicle, SRT501 or SRT1720 for 48 hours.

The linked compound also showed PKM2 activating activity in a cell based assay, and cellular growth inhibition of the A549 cancer cell line.

Designing specific physical characteristics of scaffolds may become essential part influencing pharmacological activity of cell based medicinal products, and discern TECP from typical pharmacological products.