Garcia, J. G. et al. Sphingosine 1-phosphate promotes endothelial cell barrier integrity by Edg-dependent cytoskeletal rearrangement.
As a result, the soil solution has to pass through a cell barrier in which uptake can be metabolically controlled.
A nanoparticle working concentration of 250 µg/ml was chosen for all subsequent nanoparticle transport studies through placental cell barrier models over a period of 24 h.
Kugler, S. et al. Pertussis toxin transiently affects barrier integrity, organelle organization and transmigration of monocytes in a human brain microvascular endothelial cell barrier model.
DSS chemically disrupts the epithelial cell barrier and leads to increased penetration of bacteria resulting in inflammation and colonic tissue damage.
Ye, S. Q. et al. Pre-B-cell-colony-enhancing factor is critically involved in thrombin-induced lung endothelial cell barrier dysregulation.
Pulmonary gas exchange in the lung is accomplished by the alveolar-capillary structure, which consists of an endothelial and an alveolar epithelial cell barrier with their individual basement membranes fused together in order to facilitate diffusion1.
Gut barrier integrity is maintained by the tight junction proteins such as claudins (Cldn), Zona occludin -1 (ZO1), and occludin (Ocln) that are critical for epithelial cell barrier functions8,9.
With respect to size-dependent and reduced transport of bigger 490 nm polystyrene nanoparticles, BeWo b30 and ACH-3p cell barrier displayed lower permeability than JAR and Jeg-3 day 7 post seeding.
Moreover, the barrier capacity of the co-culture was equal to the one of the BeWo layer, which indicates that the BeWo cells constitute the key cell barrier layer of the placenta for paracellular transport.
There are few examples known in the human body other than the interstitial space between cells, the renal glomerulus and the space of Disse, where fluid is in direct contact with matrix proteins without an intervening cell barrier.
