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Di Liberto, G. et al. Neurons under T cell attack coordinate phagocyte-mediated synaptic stripping.
Tumor targeting of a superantigen leads to a powerful T cell attack against the tumour tissue.
Type 1 diabetes mellitus (T1DM) is a chronic autoimmune disease characterized by the destruction of insulin-secreting β cells upon autoreactive T cell attack.
Koehler, H., Kofler, D., Hombach, A. & Abken, H. CD28 costimulation overcomes transforming growth factor-β-mediated repression of proliferation of redirected human CD4+and cells cells in an antitumor cell attack.
Cell attack: Cancer cells in tumors treated with salinomycin a drug that specifically targets cancer stem cells–have a less malignant appearance (right) and look more like differentiated cells than untreated cells (left).
The protein sits on the surface of T cells and helps dampen the activity of the cells after an immune response, but tumors have found ways to hide from T cell attack by flipping on the PD-1 switch themselves.
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We revealed that a CD28 CAR redirected T-cell attack is accompanied by higher numbers of Treg cells infiltrating the tumor and is less efficient against cancer cells in presence of Treg cells than a CD3ζ CAR T-cell attack.
Down-regulation of survivin by siRNA or pharmacologically in RMS cells increased their susceptibility toward a T-cell attack, whereas induction of ICOS-L did not.
Taken together, these findings suggest that functioning of the MHC class I APM above a certain threshold level is a necessary condition to respond to immunotherapies based on T-cell attack.
Tumor cells utilize the PD-1-PD-L1/2 pathway to evade immune-cell attack [ 61].
We observed that these cells maintained their susceptibility to MEDI-565/T-cell attack after prolonged treatment in vitro.
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