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Histological analysis provided evidence of tissue remodelling and cell alignment.
Moreover, 3-dimensional unit cell alignment of the patterns is illustrated.
Both cell alignment and elongation increase with increasing aspect ratio, and even a shallow grating (aspect ratio of ∼0.05) is sufficient to induce 80% cell alignment.
Cell alignment with the pattern is maintained as cells grow to form a confluent monolayer across the entire substrate surface.
The composite scaffolds exhibited good biocompatibility and facilitated cell alignment and proliferation in vitro.
Cell electro-fusion includes four steps, cell alignment, cell electroporation, reconstruction of cytomembrane and cytoplasm exchange.
Fb-free MP films were not effective in cell alignment, and clumps were formed.
Co-cultured constructs exhibited significantly increased cell alignment (p < 0.0002), which was eliminated by MMP inhibition.
Furthermore, nanometer-patterned Ti surfaces induced endothelial cell alignment similar to the natural endothelium.
The anisotropic CG scaffolds also provided critical contact guidance cues for cell alignment.
Both scaffolds improved the cell alignment along the channels as compared to the control group.
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