As expected, G0/G1-phase cells in RA-treated P19 cells had increased compared with non-treated cells, in agreement with RA-induced cell cycle arrest and neuronal differentiation in P19 cells.
Interestingly, both IL-6R and gp130 were overexpressed in normal plasma cells compared to B cells, in agreement with the known survival effect of IL-6 on plasma cells [ 26].
This is a minor issue because the inverse information matrix scales with the volume of the unit cell in agreement with the conclusions of the derivation.
In normal cells, GATA3 expression reduced the population of progenitor cells, in agreement with a role in differentiation of these cells into mature luminal cells [ 4, 66, 72].
Protein content changed significantly but mRNA did not, suggesting that UCP2 is translationally controlled by glutamine in INS-1E cells, in agreement with studies in other cells [19,20].
These data suggest that the MEK-ERK pathway is largely responsible for growth-factor induced cortactin S405/418 phosphorylation in HNSCC cells, in agreement with previous findings in other cell types [40].
We then show that absence of SCL leads to rapid conversion of blood-fated cells into functional cardiac and paraxial cells, in agreement with the notion of cellular plasticity.
In the adult, when Nestin is now present, we show that Nestin-Cre activity represents only a minute fraction of Nestin-positive cells (0.7% of total anterior lobe cells), in agreement with others [4], [7].
These data suggest that Fbw7 mRNA is enriched in ductal cells, in agreement with substrate stabilization predominantly in this cell type after Fbw7 loss.
