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Liu, Q.R. et al. Addiction molecular genetics: 639,401 SNP whole genome association identifies many "cell adhesion" genes.
Wu, Q. & Maniatis, T. A striking organization of a large family of human neural cadherin-like cell adhesion genes.
First, pRb controls the expression of cell adhesion genes.
Table S2 shows cell adhesion genes activated by pRb while table S3 shows cell adhesion genes repressed by pRb.
We found that the top GWAS and differentially expressed candidates were enriched in cell adhesion genes.
Eight up-regulated and 9 down-regulated cell adhesion genes were chosen from the microarray list of pRb-affected cell adhesion genes and validated by qRT-PCR (Fig. 7).
Together, these results show that pRb dramatically affects the transcription of a wide array of cell adhesion genes.
The cluster heat map of cell adhesion genes affected by the mode of cortisol delivery is shown in Figure 4A.
Microarrays comparing pRb-expressing and pRb-deficient osteoblasts showed that pRb controls the expression of a number of cell adhesion genes, including cadherins.
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The enhancement in these cell-cell adhesion genes may provide better cell-cell communication and coordination during spheroid formation.
Conversely, expression of various epithelial cell-cell adhesion genes such as claudin 3, claudin 4, claudin 7, occludin and E-cadherin was significantly lower as previously reported [ 5].
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