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In fact, we have identified several non-catalytic activities of heparanase (i.e., cell adhesion, gene transcription, signal transduction) [9], [51], [57] thought to be mediated by yet unidentified cell surface receptors [57].
Cell adhesion gene expression was also suppressed by CR diet.
Interestingly, the cell adhesion gene CYR61 had a dramatic decrease (7 fold) in expression.
There was also a significant increase of protein modifications and additional cell adhesion gene expression specific for the second transition.
In this study, the most significantly influenced (upregulated) cell adhesion gene in the MPEG- b-PLLA modified PLLA compared with the PLLA surface was CDH1 (12.14-fold 12.14-fold
Furthermore, accumulated studies indicate that non-ER CRT also regulates important biological functions including cell adhesion, gene expression, and RNA stability.
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First, pRb controls the expression of cell adhesion genes.
Table S2 shows cell adhesion genes activated by pRb while table S3 shows cell adhesion genes repressed by pRb.
We found that the top GWAS and differentially expressed candidates were enriched in cell adhesion genes.
Eight up-regulated and 9 down-regulated cell adhesion genes were chosen from the microarray list of pRb-affected cell adhesion genes and validated by qRT-PCR (Fig. 7).
Together, these results show that pRb dramatically affects the transcription of a wide array of cell adhesion genes.
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