Poorly differentiated thyroid carcinomas presented molecular signatures related to cell proliferation, poor prognosis, spindle assembly checkpoint and cell adhesion.
Various factors are critical for centrosome clustering, such as cortical actin, the spindle assembly checkpoint (SAC), cell adhesion and polarity regulators, the Ndc80 microtubule-kinetochore attachment complex, augmin complex members, and microtubule motors (e.g., dynein and HSET).
For example, matrix metalloproteinases may act in transformation by inducing apoptosis in anchorage-dependent cells and/or by modifying cell cycle checkpoints through alterations in cell adhesion.
In addition to proteins that organize microtubules at the spindle poles, we identified novel roles for the spindle assembly checkpoint, cortical actin cytoskeleton, and cell adhesion.
As a result, Wee1 may be more than a G2 checkpoint nullifier, since it also affects cell adhesion molecules.
Beckerle, M. C. Cell Adhesion.
The evolution of cell adhesion.
The reduced cell adhesion enhances cell apoptosis25.
Buckley, C.D. et al. Cell adhesion.
Buckley, C. D. et al. Cell adhesion.
The adhesion molecule Necl-3/SynCAM-2 localizes to myelinated axons, binds to oligodendrocytes and promotes cell adhesion.
