Exact(1)
34 In gallbladder, TNF-α and IL-1α were found to directly affect epithelial cell absorptive function of the gallbladder wall.
Similar(59)
Inside the crypts are actively dividing progenitor cells that differentiate into secretory (goblet cells), absorptive cells (enterocytes) and other cell types (e.g. Paneth cells) (Neal et al., 2011; Potten et al., 1997).
In thus transplanted mice, representatives of all cell lineages derived from intestinal crypt stem cells (absorptive columnar, enteroendocrine, goblet and Paneth cells) showed expression of chromosomal markers characterizing donor BMD cells.
It was demonstrated to be under the control of the secretion gene only in intestinal Paneth cells and absorptive cells of the right colon.
Specimens were graded using a categorical construct that included the identification of normal mucosa, superficial gastritis, gastric atrophy (loss of glandular tissue and fibrous replacement) and intestinal metaplasia (presence of goblet cells and absorptive cells), according to the most advanced lesion observed in each set of biopsy samples from each subject.
ACE is constitutively expressed on the surface of endothelial cells, different absorptive epithelial and neuroepithelial cells [4] [7], and cells of the immune system (macrophages, dendritic cells) [8] [9].
The small intestinal epithelium is composed of four distinct differentiated cell types: absorptive enterocytes, mucus-producing goblet cells, hormone-secreting enteroendocrine cells, and antibacterial peptide-secreting Paneth cells which in contrast to the other cell lineages remain at the crypt base.
EBs further differentiate into two cell types: absorptive enterocytes (ECs) and enteroendocrine cells (ees) [ 57, 58].
In addition, as organoids not only consist of intestinal stem cells, but also their differentiated progeny, such as Paneth cells, Goblet cells and mature absorptive epithelial cells, toxicological studies can be performed in a model system resembling very closely the situation of the intestinal epithelial layer in vivo.
The descendants of the stem cells actively proliferate, gradually differentiate into absorptive cells, goblet cells, endocrine cells, and Paneth cells as they migrate along the crypt-villus axis, and finally undergo apoptosis at the tip of villi.
In mouse intestine, the effects of genetic ablation of bone morphogenetic protein (BMP) receptors from the intestinal epithelial lineage indicate that the BMPs produced by one class of terminal cells (enterocytes, or absorptive cells) feed back to promote differentiation of a common progenitor into enteroendocrine cells, an alternate lineage branch [ 45].
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