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Cell Biol.
In the here reported model (introduced by Heumann et al. [J. Cell Biol.
Perry, S. Gilchrist, R.A. Baldock, W.A. Bickmore, Spatial organization of active and inactive genes and noncoding DNA within chromosome territories, J. Cell Biol.
The situation can be interpreted as a manifestation of the stationary states of macromolecules, which are represented by monoexponential components of the basic reaction (Monod-Wyman-Changeux model) Monod et al. (J Mol Cell Biol 12 88 118, 1965).
The data of Danieli et al. (J. Cell Biol. 133:559–569, 1996) and Blumenthal et al. (J. Cell Biol. 135:63–71996996) for fusion between hemagglutinin (HA -expressing cells and fluorescently labeled erytHA -expressingeen analyzed using a recellsy published comprehensive mand action kinetic model fluorescentlyed fusion.
Islam, T. E. Carey, G. T. Wolf, M. J. Wheelock, and K. J. Johnson, "Expression of N-Cadherin by human squamous carcinoma cells induces a scattered fibroblastic phenotype with disrupted cell-cell adhesion," J. Cell Biol.
In contrast, there are seven plakins found in mammals and most of them have alternatively spliced forms leading to a very complex group of proteins with potential tissue specific functions [Jefferson, J.J., Leung, C.L., and Liem, R.K. (2004). Plakins: goliaths that link cell junctions and the cytoskeleton. Nat Rev Mol Cell Biol 5, 542 553.].
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Slm1 and Slm2 were identified originally as PP2B/calcineurin-binding proteins nearly contemporaneously in three different labs [Bultynck G et al. (2006) Mol. Cell. Biol. 26: 4729-4745; Tabuchi M et al. (2006) Mol. Cell. Biol. 26 : 5861 -5875; Daquinag A et al. (2007) Mol. Cell. Biol. 27: 633-650].
The recent characterization of potential SINE-LINE partner pairs that share common 3′ end sequences concurs with this model and has led to a potent picture of tRNA-derived SINEs consisting of a tripartite functional structure (Mol. Cell. Biol. 16 (1996) 3756; Mol.
In addition, this was very recently shown by Shilatifard and colleagues (Mol. Cell. Biol. doi 10.1128/MCB.01181-13").
We were aware of the CBX result (Ren and Kerppola, 2011, Mol. Cell. Biol)., but it is not interpreted easily because the effects of REST knockdown were opposite depending upon the chromatin context.
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