To increase the study's trustworthiness the researchers were from varying disciplines and contributed with expertise in CD research, pediatric medicine, qualitative research, and nursing.
This latter finding provides a better explanation than the current dogmas for how the disease develops in patients bearing these mutations, which is a highly controversial issue that has been dogging the field of CD research.
These new variants represent markers of disease risk and turn the identification of the causal genes and the causal variants inside the associated loci, as well as their precise biological role on the disease, into a major challenge in CD research.
In this work, we characterized two moAbs raised against the immunotoxic gliadin 33-mer peptide, each of which showed suitable epitope recognition for fundamental and practical applications in CD research.
This implies that CD research should prioritize identification of new environmental agents that could contribute to new preventive strategies in addition to infant feeding, which is already implemented in both Europe and the US [ 35].
The authors would like to acknowledge Dr. Paolo Donini, Dr. Joanne Ross, and Dr. Ferruccio Gadani for supporting the Cd research at PMI and thank Dr. Ferruccio Gadani for being the principal initiator of the TGI.
✓ = tested; ✗ = not tested; * Reported in Cano et al 2004 [ 6]; ** Reported in Cano et al 2006 [ 28]; *** Although not including MID in our responsiveness paper (Cano et al, 2006 [ 28]), we include a comparison of relative responsiveness to existing PROs used in CD research in order to increase the interpretability of CDIP-58 change scores against these measures.
LM, MM, BM, FAG, IM, and CD researched data and contributed to their interpretation.
CD and RS designed research; CD, MK, RS, AM, HR and RS performed research; CD, KS, MS and RS analyzed data; CD and RS wrote the paper.
