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Behind this concern is a commitment to evidence-based practice, but as of yet there has been very little discussion regarding how the principles of evidence-based public health (EBPH) might be applied to CCA activities.
Finally, a fifth modification allows for the explicit addition of intervention monitoring and evaluation as a distinct step to satisfy the need for iterative management processes that have become a staple of CCA activities.
For instance, step 1a definition of the decision space makes explicit the scoping consideration that adaptation activities are typically organized at a particular jurisdictional level [city or county, state (in the case of the United States), regional consortium, or country], and that CCA activities are often nested within multiple relevant jurisdictions.
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Further studies are required to determine the molecular mechanisms and active ingredients of all test materials particularly AL, which are responsible for their anti-CCA activities.
Each test material was given at the three dose levels (low, medium, and high) as described previously for the assessment of anti-CCA activities.
PC produced no significant anti-CCA activity.
The anti-CCA activity of PPF extract was moderate; nevertheless, it exhibited diverse pharmacological activities.
In the present study, the CUR compound was shown to possess moderate anti-CCA activity.
In our previous study, the anti-CCA activity of ZO was demonstrated in OV/dimethylnitrosamine induced-CCA hamster model [ 10].
Significant anti-CCA activity of rhizome extract of ZO was also observed in the xenograft mouse model.
The ethanolic extract of AL was shown to possess the most potent anti-CCA activity similar to 5-FU with regards to the reduction of tumor mass, prolongation of survival time, and inhibition of lung metastasis.
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