The "cautious" (or class A) monooxygenases, which are typified by the extensively studied p-hydroxybenzoate hydroxylase (PHBH) (reviewed in refs (31− 33)), have a stringent substrate specificity and also maintain tight regulation over the reductive half of their reaction cycle.
As mentioned previously, "cautious" (or class A) monooxygenases get their name from the fact that in these enzymes, NADPH will reduce FAD only when substrate is bound, thus limiting oxidative uncoupling.
Some are worried too that the CUP will frighten off cautious, middle-class converts to the cause.
How do responsible, cautious, middle-class burghers defend themselves against the traditional scourge of civilization -- young men willing to risk everything because they have nothing to lose?
Dhalia Mignouna, 19, a sophomore from Virginia who is studying economics, said students were feeling "more cautious" since classes began last week.
By and large, I think because management is cautious and the class isn't so great, they'll wait and see".
Mr. Lee, who taught Ms. Rees, Mr. Green and Mr. Brown in his third-year directing class, is cautious about too much talk of a new wave, noting that very few of the directors who emerged in '91 are still making features.
First, investors are still unfamiliar with, and cautious about, the asset class.
Although we have not systemically examined doctors' rationale of prescribing, clinical experiences with adverse effects of aspirin may have led to cautious use of this class of drug.
He is even prepared to examine means-testing universal child benefits, though he is cautious of destroying "middle-class solidarity" with the welfare state.
