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Phosphorylated prodrugs such as ganciclovir, acyclovir or valacyclovir are incorporated into the newly synthesised DNA causing termination of DNA synthesis and, thus, cell death.
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In such scenarios, peak AGN emission is expected to correspond to, or even to cause termination of major star-formation activity in the host spheroid.
What causes termination of re-replication following alternative transposition in maize?
This might indicate that maternal contamination with these types of chemicals, at concentrations that do not cause termination of pregnancy, may cause dysfunction in pregnancy and fetal development.
Regulators of G-protein signaling have an enhancing effect on the intrinsic GTPase activity of G-alpha subunits and thus can cause termination of the mediated signal [ 55].
This would establish a negative feedback loop, where depolarization of VC causes egg-laying, which in turn causes termination of the calcium transient and repolarization of the VC neuron.
Even though they do not cause termination of pregnancy, low concentrations of these substances could produce anomalies in the functional processes of the placenta, leading to possible disorders and/or abnormalities later on in pregnancy.
As B symptoms represent the inflammatory process, we speculated that absence of TNFAIP3 causes termination of the inflammatory process to fail, resulting in continuous activation of NF-κB signaling and classical Pel-Ebstein fever in cHL patients.
Lgn-R was shown previously to affect ligule and auricle development (Moon et al. 2013) but can also cause termination of the development of the maize plant before ear and tassel production.
The identified base change introduces a PTC at amino acid 249 (E249X) and, if translated, would cause termination of the protein sequence just two amino acids upstream of the zinc finger domain (Fig. 1D).
The behavior of reverse transcriptase at the cross-linked nucleotide is also exploited by iCLIP, which takes advantage of the fact that often the amino acid tag causes termination of reverse transcription at that site to determine the precise location of the termination (and thus the cross-linking) site [ 79].
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