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At the F.D.A., he recommended against the approval of Rezulin, a diabetes drug that was later withdrawn for causing severe liver damage in patients.
Significantly, they found that expression of dominant negative TEAD2 prevents YAP-driven cancer[91] without causing severe liver abnormalities[92].
Hepatitis C virus (HCV) infects ∼170 million individuals, causing severe liver disease and hepatocellular carcinoma (HCC).
The hepatitis C virus (HCV) infects nearly 3% of the World's population, causing severe liver disease in many.
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The disease can cause severe liver damage, cancer and death.
But Dr. Peters said Rezulin's potential to cause severe liver damage was clear even before it was approved.
Small amounts were harmless — false morels have long been eaten in Scandinavia — but even the tiniest overdose could cause severe liver and kidney damage.
[C5.] Warning on a Biogen Idec Drug In a setback for Biogen Idec, regulators said its multiple sclerosis drug Avonex might cause severe liver damage in rare cases.
Because Ketek has been reported to cause severe liver injury in patients after only a few doses, Dr. Jenkins was asked how patients could follow this advice.
Critics say the evidence was clear in the clinical trials that Rezulin could cause severe liver problems but that the agency had approved it for marketing without proper warnings or recommendations that it be monitored.
Although both ether and chloroform were employed in anesthesia for more than a century, their current use is severely limited by their side effects; ether is very flammable and explosive and chloroform may cause severe liver toxicity in some patients.
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CEO of Professional Science Editing for Scientists @ prosciediting.com