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Loss of PTEN is a common genomic aberration in castration-resistant prostate cancer (CRPC) and is frequently concurrent with ERG rearrangements, causing resistance to next-generation hormonal treatment (NGHT) including abiraterone.
To address this threat, we need to put a stop to inappropriate, nonmedical antibiotic uses causing resistance.
The likelihood of culture causing resistance to change seems to be even greater within a complex set of cultural context.
In contrast, V333W and N337L mutations led to less stable microtubules, with the V333W causing resistance to PLA and PTX, but not LAU, and the N337L causing resistance to PLA, LAU, and PTX.
Using these tumor models, we have also identified genetic alterations promoting tumor metastasis and causing resistance to PI3K-targeted therapy.
Synthetic preservatives and fungicides have been used for decades to control fungal spoilage, however, the indiscriminate use of these substances has caused health problems for humans and animals due their carcinogenicity, teratogenicity and acute toxicity [3], environmental contamination, besides causing resistance in pathogens [4].
Similar(8)
Hotamisligil's experiments showed that not only is TNF-alpha produced by fat; it also can cause resistance to insulin.
However, mutation of HSV-TK or VZV-TK can cause resistance to acyclovir.
This causes resistance against the drug.
Here, the impact of renewable energy might cause resistance.
"Even the slightest friction will cause resistance, and create heat and stop the thing from working properly.
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