Sentence examples for causing replication from inspiring English sources

We reasoned that upon ssDNA exposure during DNA replication, Flex1 could form secondary structures causing replication stalling and DSB formation.

In some cases, as in herpes infections, the viral nucleic acid may remain in the host cell without causing replication of the virus and damage to the host (viral latency).

In contrast, SCEs can be induced by various genotoxic treatments causing replication arrest.

It is thought that twinkle mutations result in an accumulation of replication intermediates, causing replication stalling and eventually depletion.

Moreover, a dominant negative mutation in MRE11A in MMR deficient cancers has been shown to sensitize cells to agents causing replication fork stress [ 53].

However, in certain mammalian cell lines, fork reversal has been implicated in replication restart mechanisms under conditions causing replication stress (Berti et al., 2013; Zellweger et al., 2015).

Upon phosphorylation by HSVtk, GCV is known to kill dividing cells by incorporating into nuclear DNA, causing replication-dependent double strand breaks.

Loss of these checkpoint proteins causes replication fork collapse and chromosomal rearrangements which may ultimately predispose affected individuals to cancer.

This overestimation of the genetic effect may cause replication studies to fail because the necessary sample size is underestimated.

However, this binding to DNA will cause replication errors in living tissue, possibly leading to mutations and cancer.

On the other hand, in rapidly dividing cells, unrepaired DNA damages that do not kill the cell by blocking replication will tend to cause replication errors and thus mutation.