Brochothrix thermosphacta is a psychrotrophic species commonly involved in the spoilage of meat and often recognized as the dominant organism causing off-flavours.
The resulting narrow shelf may play a significant role in the preservation of later sequences, particularly in light of the continued uplift of the margin causing off-shelf sediment bypass where TST and HST sequences may not be preserved.
During clinical loading of an implant, the direction of loading is rarely along its central long axis, so the applied occlusal force is frequently in a direction that creates a lever arm, causing off-axial and bending moments in bone [16].
Excessive water in the landfill is causing off-site violations, some intentional it seems".
"They're just pretending to address the issue of overdrugging with a wink and a nod -- the Justice Department gets billions from drug companies for causing off-label uses that aren't supported by the law, while CMS is continuing to pay for these same prescriptions," Gottstein observes.
Critically, those researchers developing novel antibiotics need to select out the proteins that show close homology to any human proteins, as future inhibitors are likely to cross-react with the host protein, causing off-target toxicity effects later in clinical trials.
This reduction is made because the seed region of the siRNA seems to play a significant role in causing off-target effects.
The main caveat of modulating natural combinatory elements is that they can potentially target many mRNAs or proteins that are unrelated to the particular pathology of interest, causing off-target effects.
A rift between Cruyff, a former player and manager at Ajax, and his four fellow supervisory board members had caused off-field disharmony at the Amsterdam club.
Radionuclides leaking out of the target tissue, whether individually or as nanoparticulate may cause off-target toxicity.
