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Cytokines have a major role in causing joint damage.
Rheumatoid arthritis (RA) is a common chronic inflammatory disease causing joint damage, disability, and reduced life expectancy.
Concerns about exercise causing joint damage are not challenged during usual primary care management, nor are the necessity and potential benefits of exercise explained and emphasised.
Rheumatoid arthritis (RA) is a chronic inflammation disease characterised by hypertrophy of the synovial membrane, ultimately causing joint damage due, in part, to the sustained production of inflammatory cytokines such as TNFα, IL-1β and IL-6.
The pathogenesis of RA comprises a complex inflammatory response, involving macrophages, synoviocytes, T cells, B cells, proinflammatory cytokines and autoantibodies, causing joint damage and resulting in erosion of bone and cartilage [ 5, 6].
Similar(54)
Trovan belonged to the quinolone class of antibiotics, and quinolones had caused joint damage in experiments on young rabbits and puppies.
A. The good news is that the usual painless joint cracking or popping does not represent an early form of arthritis, nor does it cause joint damage (despite what our mothers told us about cracking our knuckles).
If left unregulated, these inflammatory pathways can cause joint damage.
Rheumatoid arthritis (RA) is a chronic inflammatory disease that can cause joint damage, extra-articular manifestations and disability.
Uncontrolled active RA causes joint damage, disability, decreased quality of life, and cardiovascular and other co-morbidities.
Alternatively, the TNF cytokine may cause joint damage only after it exceeds some threshold that is greater than that required to cause inflammation.
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