"causing difficulty in" is correct and usable in written English.
You can use it when describing something that is making a situation more complicated or difficult. For example, "The increased complexity of the project is causing difficulty in completing it on time."
In addition, the high conformational flexibility of certain transmembrane proteins reduces sample homogeneity causing difficulty in crystallization.
The commonly used ultraviolet (UV -curable mono-, di- or mUV -curablenal vinylated monomers are often volatile, causing difficulty in kinetics analysis such as phoro-differential scanning calorimultifunctional).
However, the number of parameters would be enormous, causing difficulty in the training.
An important problem of the Semantic Web is that there is no generally-accepted standardized concept in use today, causing difficulty in the ontology design.
Without the opportunity to reorganise our memories during sleep, dreams intrude into our waking lives, causing difficulty in distinguishing our inner lives from reality.
In general glass frit samples contain small quantities of magnesium, which form Mg-EDTA complexes and may react with manganese releasing the magnesium ion, causing difficulty in the end point detection.
And that is causing difficulties in emerging economies.
This slightly alters the paper's dimensions, causing difficulties in register.
However, complex components of crude oils such as asphaltenes may stabilize these emulsions, causing difficulties in efficient separation.
The shape of the scour hole affects the predominant natural frequency of the pier, causing difficulties in practical measurements.
Wellbore storage may mask the flow periods in the early time period causing difficulties in the analysis of welltest data.
