Sentence examples for causing differentiation from inspiring English sources
Inhibition of histone deacetylases (HDACs) has diverse effects on cell function, such as causing differentiation, growth arrest and apoptosis in nearly all types of tumor cell lines.
Constitutive PU.1 expression is essential for viability of haematopoietic stem cells (HSCs) [18], with a subsequent reduction in expression causing differentiation into megakaryocyte, B and T cell phenotypes and increased expression causing differentiation into macrophages [19].
Perphenazine treatment, which induces secretion of prolactin, causing differentiation of the mammary gland but not resistance to tumors [ 9], failed to activate p53 in this experiment.
In the cerebellum, Ptf1a expression triggers Neph3 expression and determines neuronal precursor cell fate by causing differentiation into GABAergic subpopulations (Hoshino et al. 2005; Mizuhara et al. 2010; Pascual et al. 2007).
In mESC, Sirt1 impedes p53 nuclear translocation in response to mild oxidative stress; Sirt1 downregulation allows acetylated p53 to enter the nucleus and inhibit Nanog expression, causing differentiation [ 19].
Ecological contrasts of a microsite are excellent critical tests for evaluating the dynamics of genome and phenome evolution and assessing the relative importance for adaptation and speciation of the evolutionary forces causing differentiation (Nevo 1995b).
Through PPAR-γ, thiazolidinediones increase the concentration of high molecular weight adiponectin42, reduce adipose tissue inflammation, and cause differentiation of preadipocytes43.
In leukemia, high doses of retinoic acid caused differentiation of stem cells into functional blood cells, helping to successfully treat patients.
Blocking the IGF-II/IGF1R pathway reduced survival and clonogenicity of human ES cells, whereas inhibition of the FGF pathway indirectly caused differentiation.
The β-GAL/CAT reporter parasite provides a method to quantify and compare agents that cause differentiation in T. gondii.
The dynamic transformation of the regional plate margins caused differentiation of the intra-platform paleogeomorphology, which imposed changes in the development of sedimentary facies contemporaneous with the development of intra-platform shoals.
