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Conventional infused 5-FU regimens require central venous access via a Port-a-Cath®, Hickman catheter or Groshong and the use of portable pumps, causing considerable inconvenience to patients.
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Average delays range from 45 min to 3 h in different countries and cause considerable inconvenience to passengers as well as significant operational and financial impact for railways.
A central argument for those who advocate wide-spread use of antibiotics for TD is that it can cause considerable inconvenience, ruin holidays and cause financial loss and that it may cause chronic gastro-intestinal complaints [ 6, 11, 12].
While most of those harmful incidents were 'low harm', they represent issues that still caused considerable inconvenience to patients (for example, additional visits, phone calls, and delayed resolution of their problems).
Another disadvantage is the need to wear a buster collar for two to three weeks, which can cause considerable inconvenience if the dog is large and goes blundering into furniture at home.
A major power blackout causes considerable damage and inconvenience to the community and can threaten lives.
It can even cause them considerable inconvenience.
It has caused considerable public interest.
Typhoon Linda caused considerable deaths in Vietnam.
Delta caused considerable damage in the Canary Islands.
ISH causes considerable tissue section shrinkage (80%).
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com