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Accumulation of arachidonic acid would lead to activation of TREK, thereby causing an efflux of K+ and allow for membrane hyperpolarization to decrease cell excitability.
Lubiprostone selectively stimulates type 2 chloride channels in epithelial cells thereby causing an efflux of chloride into the intestinal lumen.
Our results can be interpreted in terms of BL causing an efflux of calcium from chloroplasts, and its continuous chelating by extracellular EGTA.
Vidal and colleagues considered that the HER4 cell-killing intracellular domain 4ICD might be responsible for association with overall improved patient prognosis [ 48] by accumulating in mitochondria, causing an efflux of cytochrome c and resulting in mitochondrion-regulated apoptosis [ 49].
Positive inotropic effects of digoxin are realized by inhibition of the Na+/K+ ATPase in cardiac myocytes, causing an efflux of Na+ and a net increase in Ca2+ (see ref. 12).
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This is a reverse-Na+/Ca2+exchange that causes an efflux of Na+ and an influx of Ca2+ during ligand-induced motility initiation in herring sperm (Vines et al. [2002]).
Activation of ClC-2 channels causes an efflux of chloride into the lumen of the GI tract, followed by an efflux of sodium ions in order to maintain isoelectric neutrality.
Further studies revealed that the cotreatment of SBL and TRAIL enhances the cleavage of Bid, a proapoptotic member of the Bcl-2 family, that is cleaved by activated caspase-8 and subsequently causes an efflux of cytochrome c from the mitochondria.
We found that Aβ treatment of wildtype neurons caused an immediate efflux of K+, which gradually returned to homeostasis within 10 minutes.
Expectedly, ionomycin causes a rapid efflux of calcium out of the PV into the parasite cytoplasm and to the ambient media and thus diminishing the concentration gradient at the parasite plasma membrane.
MDMA, on the other hand, causes a rapid efflux of dopamine (DA) and serotonin (5-HT) in several brain areas immediately after it is administered, including the striatum and nucleus accumbens (NAc), [ 11].
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