Sentence examples for causing an accumulation of from inspiring English sources

Several studies have identified the PCA decarboxylase as a metabolic bottleneck, causing an accumulation of PCA that subsequently reduces muconate production.

Obstruction or constriction of the urethra usually produce the same results: urination becomes difficult or impossible, causing an accumulation of stagnant urine in the bladder, and this usually leads to severe infection.

This creates chronic environmental concerns and pushes cities to grow in a disorderly manner, causing an accumulation of urban problems.

On the cellular level, there are two basic mechanisms causing organ dysfunction: cell death resulting in the reduction of cell numbers, and cellular dysfunction causing an accumulation of cells not able to support major organ functions.

Disulfiram (Sigma-Aldrich, St Louis, MO, USA) irreversibly inactivates aldehyde dehydrogenase, preventing the conversion of acetaldehyde to acetate and causing an accumulation of acetaldehyde [14], [17], [19].

We have demonstrated for the first time that Hes1 potentiates T cell lymphomagenesis, by up-regulating a subset of Notch target genes and by causing an accumulation of ISP thymocytes particularly vulnerable to oncogenic transformation.

The inflammation causes an accumulation of fluid in the pericardial sac, which encases the heart.

This causes an accumulation of the more resistant fraction (humates and tannins) in the substratum.

CYP17 hydroxylase inhibition prevents the synthesis of adrenal glucocorticoids and causes an accumulation of circulating mineralocorticoids.

Epibenthic suspension feeders caused an accumulation of fine particles and organic content in the sediment.

Impairment of AGA activity causes an accumulation of the AGA substrates, glycoasparagines, in lysosomes, and results in progressive mental decline of the patients.