"It is unfortunate that a problem with this subsystem caused a termination before we could light the scramjet engine," Charlie Brink, of the Air Force Research Laboratory at the Wright-Patterson Air Force Base in Ohio, said in a statement.
However, depletion of either Nrd1 or Nab3 caused a termination defect on the 5-kb HPF1as-RNA, suggesting that Nrd1 Nab3 termination activity is not fully dependent on Ser5 phosphorylation of the CTD.
First, a defect in one gene by a nonsense mutation or a frame-shifting indels causing a premature termination codon could be a cause of genetic diseases including complex diseases[40].
As a consequence of blocking splice-donor sites three scenarios are possible: 1) the removal of the targeted exon, 2) the use of a cryptic splice donor site, often causing a premature termination codon, or 3) a retention of the targeted intron.
Despite a strong increase in HDL levels, mortality and morbidity in patients receiving the drug was increased causing a premature termination of a total of six studies, including the ILLUMINATE study [5].
Direct sequencing of BRCA2 coding exons of patients carrying the shared haplotype, allowed the identification of a 'frame-shift' mutation at codon 2867 (8765delAG), causing a premature termination-codon.
One novel single base deletion (c.3830delT), causing a frameshift and a termination codon was found to be associated with the severe form of FAP syndrome.
The statement exit causes a successful termination of a procedure.
The brachypodism mutation is a frame shift of Gdf5 that causes a premature termination codon, resulting in a null allele.
In addition, we observed that one non-synonymous SNP in an E1-E2 ATPase gene (Glyma06g47300) caused a premature termination codon.
