Exact(2)
Exacerbations not only incur significant morbidity and mortality, but also negatively impact the natural history of the disease causing a progression in disease severity.
The SMC is initially damaging (causing a progression of the atheroma and atherosclerotic plaque through fibroproliferation) and later in the atherosclerotic process becomes protective providing the strength of the fibrous cap [ 27].
Similar(58)
Although trastuzumab can be effective alone, cancer cells eventually develop resistance to it, causing a relapse or progression of the cancer.
However, the mechanism underlying the induction of neural-like differentiation in BMSCs in RGC-conditioned medium in our experiments is likely different from that of chemical treatments because chemical treatments cause rapid morphological changes and cell death, whereas co-culturing causes a slower progression of morphological changes and delayed cell death.
In addition, consumption of yeast (1,3 - 1,6 -beta-glucan 1,3 - 1,6 -beta-glucan 1,3 - 1,6 -beta-glucan 1,3 - 1,6 -beta-glucan
In our cohort, we found that severe HAdV-55 infection could cause a rapid progression of respiratory failure, with a very high failure rate for NPPV and IMV.
As hepatocyte apoptosis is involved in the pathogenesis of HCV infection 10, 11, the high proliferation capacity of HCV genotype 2a may cause a rapid progression of liver damage.
Monoparameter flow cytometric analysis showed that 1 h IHB exposure caused a delayed progression through S-phase, a dramatic block in G2M phase of the cell cycle and the appearance of tetraploid cell population in LoVo, LoVo/DX, MOLT-4 and K562 cells.
One possible explanation is that the acquisition of bcl-2 expression creates a restrictive environment for the expansion of genetically unstable and potentially malignant p53-deficient cells, causing a delay in tumor progression and explaining the different prognostic value of bcl-2 and p53 [ 14].
However, it has been confirmed that the expression of piRNA pathway genes is essential for the progression of spermatogenesis, i.e. the disruption of Miwi2 and Mili genes cause a meiotic-progression defect, loss of germ cells and sterility [ 28, 29].
Remarkably, the combined treatment did not lead to severe side effects, while causing a huge impact on tumor progression.
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