Another limitation is that nearly half of the centers enrolled only 1 or 2 patients, which may have caused an inter-rater discordance of the clinical ratings, although a training and certification course was mandatory for the investigators.
Possible mechanisms causing such discordance between α and FST are geographic variation in the genomic architecture of local adaptation or in local selection pressures.
Kato, T., Iwamoto, K., Kakiuchi, C., Kuratomi, G. & Okazaki, Y. Genetic or epigenetic difference causing discordance between monozygotic twins as a clue to molecular basis of mental disorders.
The overall analysis shows that health communication is an integral part of health promotion practice in Hälsotorg and PHC but there was a dearth of consensus among health professionals on what a health promotion approach is, causing discordance in approaches and practices of health communication.
Problems arise because asymmetric cord insertions cause growth discordance as a result of unequal sharing of placental tissue.
Positive selection on non-recombining chloroplast DNA is expected to lead to a spread of the selected chloroplast haplotype across several species, causing phylogenetic cytonuclear discordance.
When ILS is the only process causing discordance, the CF of minor clades conflicting with the "main" topology is completely determined by the coalescent units (Ané 2011).
However, several reticulate evolution processes, such as horizontal gene transfer and hybridization, have been shown to blur the species evolutionary history by causing discordance among phylogenies inferred from different genes.
To assess the concordance of these algorithms and to identify sequences causing interalgorithm discordances, we applied four publicly available algorithms to the sequences of isolates from 2,045 individuals in northern California.
To distinguish intralineage processes such as gene duplications from interlineage processes (e.g. hybridization) causing tree discordances, we are mainly interested in gene copies at three different levels.
We don't anticipate that the KM or rule execution of more complex guidelines would be much different than what is presented here, but greater complexity may cause greater discordance with locally developed CDS as more opportunity for diversion from a common standard exists.
