Any toxicity that causes a discontinuation of concurrent radiation therapy for more than 6 days.
Dose-limiting toxicities will be defined as follows: Any toxicity that causes a discontinuation of concurrent radiation therapy for more than 6 days.
Although HFS is not a life-threatening toxicity, it may induce a substantial decrease of quality of life and, accordingly, may cause a delay or discontinuation of treatment (Heo et al, 2004).
Anyway, safety profile of IV or SC Lidocaine was stated for 36 patients, 13 of which suffered from a mild AE and 6 from an AE causing the discontinuation of therapy.
Among responders to CBZ, 27% of patients incurred in adverse events that directly caused interruption of treatment by the physician or a dosage reduction to a level that was insufficient to control pain, thus causing discontinuation, after a mean period of 8.6 months.
We empirically determined a regime in which seven days of PTZ treatment and seven days of subsequent PTZ discontinuation respectively cause a decrease and an increase in climbing speed of Drosophila adults.
Though seizure-like behavior was never observed in flies treated with 8 mg/ml in a chronic manner, we empirically determined a regime in which seven days of chronic PTZ treatment and seven following days of PTZ discontinuation respectively caused a decrease and an increase in startle-induced climbing speed in flies.
However, sorafenib produced the most drug toxicity causing 21%% treated dose reductions and causing 19%% discontinuation of the drug.
group, and one case of small bowel obstruction reported as an AE causing discontinuation in the celecoxib 200 mg o.d.
Patients who were previously stable on doses of brand alendronate experienced an increase in AEs causing discontinuation after introduction of automatic substitution to generic alendronate.
He was then prescribed esomeprazole because of reflux symptoms, and after 1 2 weeks a severe flare of the rash emerged, causing discontinuation of esomeprazole and referral to our department.
