Sentence examples for causes the abrogation from inspiring English sources

Marquez et al. [54] found that inhibition of Pellino-1 by miR-21 causes the abrogation of NF-κB activity and that miR-21 is up-regulated in hepatocytes during proliferation in response to NF-κB.

Chk1 inhibition caused the abrogation of SAC both in diploid and tetraploid cell lines; nevertheless, SAC is more frequently activated in untreated tetraploid cells, correlating with an elevated frequency of abnormal mitoses.

More importantly, we demonstrated that silencing BMI1 expression in two independent pGBM models not only led to significant suppression of cell proliferation and neurosphere formation in vitro, but also caused the abrogation of xenograft tumor formation in vivo in mouse brains.

This might represent a mechanism of sensitization of N202.1A breast cancer cells towards chemotherapeutic drugs and irradiation caused by the abrogation of AP-2 function.

Using an in vitro approach, we found that OX40L causes an abrogation of the RPE-mediated immunosuppression.

Inhibition of the UPS causes complete abrogation of mitophagy.

In particular, a pair of methylmalonyl CoA mutase (mcm) genes involved in polyketide precursor biosynthesis, an acyl-CoA dehydrogenase implicated in timing of actinorhodin synthesis and bldB, a developmentally significant regulator whose mutation causes complete abrogation of antibiotic synthesis belong to this category.

We suggest that potentiating the anti-cancer activity of TMZ by inhibition of PP2A is caused by abrogation of the mitotic checkpoint by enhanced phosphorylation of Plk-1 and the simultaneous inhibition of cell cycle arrest in G1/S that results from the marked reduction in p53 driven by increased pMDM2.

The G1 arrest caused upon abrogation of Hdacs1,2 functions has restricted studying the functions for these two enzymes within S-phase and in DNA replication.

We previously reported that PA14 causes near complete abrogation of a constitutively expressed luciferase reporter gene in Arabidopsis seedlings by five days after infection [7].

The reduction in ES cell proliferation caused by abrogation of BNP signaling had no effect on the undifferentiated status of the ES cells, as determined by morphologic examination (Fig. 3E) and confirmed by measurements of alkaline phosphatase activity, which revealed that the levels of self-renewal in the control siRNA- and BNP siRNA treated cells were identical (Fig. 5A).