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The great number of these indices and the difficulties in the interpretation causes significant obstacles and unclear points during the early attempts for transition to spontaneous breathing.
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Additionally, liposomes are heterogeneous and relatively unstable, causing significant obstacles for large-scale pharmaceutical production.
Chinese investment causes significant unease here.
For some participants, housing insecurity caused significant stress and created obstacles for daily living that affected appointment adherence.
These dependences involve high-penalty mispredictions becoming serious performance obstacles and causing significant performance degradation in executing instructions from wrong paths.
It caused significant economic loss.
This caused significant distress among British Muslims.
Neither cause significant visual loss.
The depression did not cause significant damage.
This caused "significant concern" among the commission.
"It can cause significant suffering for animals.
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